Brands

PDRN & PN Injection Brands

Here, we highlight the leading PDRN and PN injection brands that are currently preferred in professional clinical settings — including their composition, product details, presentation, manufacturer information, and suggested clinical uses.

Overview

What Are PDRN and PN Injections?

In the field of regenerative injectable therapies, South Korea has made a name for itself, especially with PDRN (polydeoxyribonucleotide) and PN (polynucleotide) materials. In order to promote skin rejuvenation, hydration, and overall dermal revitalization — especially following minimally invasive procedures — aesthetic clinics have embraced these therapies.

Bio-based compounds called PDRN and PN are made from highly refined DNA fragments, usually from particular fish species like trout or salmon. They are becoming more and more important in aesthetic medicine because they help with cellular renewal, tissue restoration, and improving the quality of the skin. These formulas are produced in Korea under strict pharmaceutical-grade standards, which has led to their widespread use in clinical and cosmetic procedures worldwide.

Every material, though, has a unique function. Pharmaceutical applications and therapeutics, such as musculoskeletal restoration, tissue healing, wound recovery, and corneal and tissue repair, are especially well-suited for PDRN. On the other hand, PN, or polynucleotide, is frequently utilized in skin rejuvenation products and medical devices that emphasize fibroblast activation, collagen reformation, skin renewal, and bio-revitalization. Despite their differing applications, both PDRN and PN are excellent choices for treatments targeting skin rejuvenation and collagen remodeling.

PDRN

Polydeoxyribonucleotide

Pharmaceutical Materials & Therapeutic uses

Tissue Regeneration
Corneal Regeneration
Musculoskeletal Regeneration
Tissue Repair & Wound Healing

PN

Polynucleotide

Medical Device & Skin Regeneration

Skin Regeneration
Collagen restructure
Fibroblast stimulation
Bio-revitalization

Polymerized DNA

Cosmetic & Food Materials

Anti-wrinkle
Skin Regeneration
Anti-aging
Functional Food Materials

Leading Brands

Top 8 PDRN & PN Injection Brands

01PN Focused Line

Rejuran

Rejuran is one of the most established regenerative injectable brands, well known for its polynucleotide (PN) formulations such as Rejuran Healer and Rejuran S. These products are widely used for skin repair and rejuvenation. It is one of the first PN and PDRN products that was available in the market and thus trusted early on by several clinics and doctors in Korea. Until the present day, Rejuran remains a powerful contender in the skin regeneration products industry. Although the Rejuran PN product line is the most popular among regenerative aesthetics, there may be cons in using the product.

Best For

Professional aesthetic clinics
Deep regenerative PN therapy

Product Range

The Rejuran PN product line is available in pre-filled syringes in each of its packages.

1Rejuran Healer — for full-face rejuvenation
2Rejuran i — for thin and sensitive skin
3Rejuran s — for general scars and depressed areas
4Rejuran HB Plus — for less painful skin rejuvenation treatment

Pros

Longstanding clinical trust in the Korean aesthetic market
Multiple PN product variants under one brand
Proven its effectiveness and safety among its users

Cons

It has a premium price bracket, leaning towards the higher price range, thus making it one of the most expensive brands.
Reported injection discomfort and pain for some patients
The product remains the same without any upgrades to increase its benefits and correct its flaws.

In conclusion

Rejuran remains a reference PN injectable due to its historical presence in clinical protocols.

Rejuran Healer Rejuran I Rejuran S Rejuran HB Plus

02PN + NMN/NAD+

Cellix PN

Celix PN is the newest PN-based anti-aging product on the market. It is designed as a complete all-in-one solution that focuses heavily on high-concentration PN (polynucleotide) injectable support, suitable for microneedling protocols and professional intradermal application. It is formulated with high-potency skin-rejuvenating ingredients and infused with an anesthetic for a more comfortable experience during the procedure.

Best For

Its high levels of polynucleotides (PN) aid in the regeneration of damaged tissues.
Post-procedure recovery to enhance effects and revitalization of the skin
Provides a complete skin cellular rejuvenation with the combination of PN and NMN/NAD+
Suitable for both initial treatment and preventive care to maintain and restore normal and healthier skin conditions.
It works as an antioxidant, producing long-term regeneration and deep hydration
The glutathione in the product helps the skin glow and reduce hyperpigmentation
It also contains lidocaine, making patients more comfortable during the treatment

Product Type

Cellix PN is a regenerative/biostimulatory skin booster that comes in a ready-to-use, pre-filled syringe, where no reconstitution or mixing is needed.

Pros

High PN concentration percentage with multiple regenerative actives to enhance its effects
Comes in a pre-filled syringe format, making it an excellent way for microneedling and direct injection without the need for reconstitution
A high-efficiency and low-pain solution, integrating lidocaine, an anesthetic, into the formula
Good flexibility for dosing and protocol adaptation

Cons

May require multiple sessions as results are gradual
Availability may vary depending on the region/clinic due to its being fairly new in the market

In conclusion

For those who use the Celix PN, it is a complete cellular revitalization designed with a combination of regenerative actives that focuses on long-term revitalization, detoxification, and high-efficiency anti-aging treatments. It is ideal for patients seeking subtle, natural rejuvenation, and it supports long-term skin repair and resilience. Its syringe format makes it perfect for mesotherapy protocols, but it may require multiple sessions for optimal results. While it requires a series of treatments, its ability to enhance skin quality at a cellular level makes it a valuable option in modern aesthetic protocols.

Cellix PN

03PDRN + PN All-in-One

EXO NAD+

A developing brand formulated with a combination of various biomaterials that are beneficial for skin regeneration and anti-aging treatments. EXO NAD combines 2% PDRN and 1% PN with supportive bioactives such as exosomes, NAD (nicotinamide adenine dinucleotide), and collagen, offering a multi-functional regenerative injectable. It comes as an all-in-one product in a vial of 5 mL solution.

Best For

Clinics seeking a versatile, multifunctional regenerative formulation (NAD + PDRN + PN)
Cost-effective regenerative protocols

Product Type

EXO NAD-PDRN + PN is available in 5 mL per vial

Pros

Combines multiple regenerative components in a single formulation, making it an all-in-one anti-aging product
Its availability in a larger volume potentially reduces the cost per treatment.

Cons

Due to the product's vial format, which calls for manual syringe withdrawal, preparation takes longer. However, EXO NAD is starting to replace PDRN-based vials in the market due to its high quality and affordability.

In conclusion

Clinics now have a viable option, particularly for those looking for complete regenerative support from a single injectable product.

EXO NAD+

04PDRN-Focused

Kiara Reju

The main goal of the well-known PDRN injection Kiara Reju is to provide basic PDRN support without the need for additional extensive active ingredients. Regenerative and recovery-focused treatments frequently employ it.

Best For

Clinics that give traditional PDRN regenerative therapy top priority
Patients looking for simple tissue support without high-end PN formulations
Clinics seeking a more focused use of a comprehensive PDRN-based injectable

Product Type

Kiara Reju PDRN Skin Booster comes in pre-filled syringes, supporting ease of use and standardized dosing.

Pros

Economically convenient compared to other premium PDRN/PN products, as it comes in 3 pre-filled syringes per box.
Clinically accepted in basic regenerative protocols
One of the first PDRN formulations available in the market, earning the trust and favor of patients and clinics

Cons

Contains PDRN only, with no other upgrades limiting its use and benefits
Lacks additional advanced actives even after its longevity in the market

In conclusion

Kiara Reju is a convenient PDRN injectable, especially for routine regenerative sessions. It is one of the longest marketed PDRN-based injectables that has been clinically proven for its safety and efficacy, and has no additions to its formula to expand its benefits.

Kiara Reju PDRN

05Multiple PN/PDRN Injections

BR Pharm

BR Pharm is a major Korean pharmaceutical company with comprehensive PDRN/PN materials and injectable products. Its product line includes PN mesotherapy and PDRN solutions as part of broader regenerative offerings.

Best For

Clinics that want a manufacturer with R&D depth
Systems where multiple PN/PDRN products are required

Product Range

Varies by product (typically pre-filled or vials)

1HP Vitaran — Contains PN 20 mg/mL and consists of 1 mL x 2 pre-filled syringes; used mainly to improve skin texture, suppleness, and tonicity of the skin, especially in areas such as the face, neck, and hands.
2HP Vitaran i — Contains PN 20 mg/mL and consists of 1 mL x 2 pre-filled syringes; especially for delicate areas, such as the under-eyes, and also targets fine lines, dark circles, and skin laxity in sensitive areas.
3HP Vitaran S — Contains PN 20 mg/mL and consists of 1 mL x 2 pre-filled syringes; perfect to treat scars and depressed areas in the skin due to its highly viscous gel.

Pros

Established manufacturing expertise in PDRN/PN materials
Multiple product forms available

Cons

The product range can be complex and varied
Some items may be more focused on raw materials than finished injectables, depending on the region.

In conclusion

BR Pharm supplies both PDRN raw material solutions and finished injection products, making it a valuable brand for practices and compounding specialists.

HP Vitaran HP Vitaran i HP Vitaran S

06Balanced PN Option

Elaxen PN

Elaxen PN is a polynucleotide injectable similar to traditional PN offerings, positioned as a balanced PN option for clinics that want regenerative support without premium pricing.

Best For

Basic PN regenerative injections
Clinics that are balancing cost and effectiveness while expanding beyond PDRN protocols without entering high pricing tiers

Product Type

Elaxen PN is available in 3 pre-filled syringes per box.

Pros

Economical PN choice compared to other PDRN/PN products, as it comes in 3 pre-filled syringes per box.
Syringe format for easy professional administration

Cons

Less differentiation in active portfolio than premium options, as it contains PN only, with no other upgrades limiting its use and benefits
Lacks additional advanced actives even after its long-standing branding in the market

In conclusion

The Elaxen PN is a practical stepping stone and good introduction to clinics that are transitioning from PDRN-focused protocols to PN-based skin rejuvenation therapies.

Elaxen PN

07PN + HA + Lidocaine

Youthfill PN+

YOUTHFILL PN+ combines polynucleotide and supportive ingredients in a viscous injectable gel designed to help tissue renewal, hydration, and elasticity. It is also infused with hyaluronic acid and lidocaine for more enhanced results and overall comfort of the patient during injection.

Best For

Clinics that prefer PN formulations with enhanced hydration
Aesthetic practitioners focused on skin quality improvement
Clinics that are focused on skin elasticity enhancement and patient comfort during treatment

Product Type

It is available in pre-filled syringes in every package.

Pros

Combines PN with sodium hyaluronate (hyaluronic acid) and lidocaine, improving the patient's tolerance during injection
Designed for deep hydration and comfort, enhancing the patient's experience during treatment
Approved for its safety and use with documented approvals and certifications.

Cons

Positioned in a higher price category compared to basic PN injectables.

In conclusion

Youthfill PN+ is often chosen when clinics aim to deliver both regenerative and hydrating effects in a single injection.

YouthFill PN+

08High-Concentration PDRN (CMED)

Gold PDRN 8%

GOLD PDRN 8% focuses heavily on high-concentration PDRN injectable support, suitable for microneedling protocols and professional intradermal application.

Best For

High-concentration PDRN regenerative treatments
Clinics that integrate microneedling with injections
Clinics requiring treatment dosage flexibility

Product Type

Vial-based products

Pros

High PDRN concentration percentage
Comes in a vial format, making it an excellent way for microneedling and direct injection
Good flexibility for dosing and protocol adaptation

Cons

Marketed with a higher premium price
Requires manual syringe withdrawal from the vial, resulting in longer preparation time

In conclusion

For those who use the Gold PDRN 8%, it prioritizes and values dosage flexibility and concentration.

Gold Cell PDRN 8%

Adjunct Boosters

Other Notable Korean Regenerative Products

Additional products that may appear in clinic inventories — typically used to complement injectable protocols rather than replace primary PDRN or PN injections.

PDRN + HA + Niacinamide

Revita Skin Booster

PDRN with hyaluronic acid and niacinamide that is primarily designed as an anti-aging solution. It is marketed as a skin booster that increases the vitality of naturally damaged skin and produces whitening effects.

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Supportive Booster

Selastin EXO Plus

Considered as 5th generation skin boosters, they are designed as exosome-based supportive boosters that are also infused with PDRN, collagen, and peptides. They offer a wide range of benefits, from collagen and elastin regeneration to anti-wrinkle effects and enlarged pore reduction.

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Frequently Asked Questions

What is the difference between PDRN and PN?

PDRN consists of shorter DNA fragments, while PN typically refers to longer polynucleotide chains. Both support tissue regeneration but may be leveraged differently in clinical injection protocols.

Can these brands be used with microneedling?

Some PDRN products can be integrated into microneedling protocols based on product format and professional preference, whereas many PN injections are designed primarily for direct injection.

Are these products safe?

Most brands listed are manufactured under strict quality controls and are widely used by aesthetic professionals. Always verify certifications and follow professional administration protocols.

How do clinics choose between brands?

Selection depends on treatment goals (hydration vs regeneration), budget, format preference (pre-filled syringe vs vial), and clinic protocols.

Do these injections require anesthesia?

Some formulations include lidocaine or may be used with a local anesthetic based on practitioner preference.

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