PDRNinjection

About PDRN

Safety, Risks & Contraindications

PDRN has a strong safety profile supported by clinical research. Side effects are typically mild and resolve within 24 to 72 hours. Serious complications are rare when treatment is performed by a qualified practitioner.

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This information is educational. Your practitioner will conduct a full suitability assessment before treatment. Do not self-administer.

Common Side Effects

These effects are expected and typically resolve within one to three days.

  • Redness at injection sites - normal inflammatory response
  • Mild swelling - particularly in delicate areas (under-eye, lips)
  • Tenderness or bruising at needle entry points
  • Small raised bumps (papules) at injection sites - usually resolve within 24-48 hours

Less Common Side Effects

  • Persistent swelling beyond three days
  • Temporary numbness or tingling in treated area
  • Headache following facial treatment sessions

Rare but Serious Risks

The following are uncommon but require prompt medical attention.

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Infection

Requires immediate treatment if signs of spreading redness, warmth, or pus appear.

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Allergic reaction

Rare but possible, particularly in patients with fish allergy.

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Vascular compromise

Very rare. Risk minimised by practitioner training and correct technique.

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Granuloma formation

Uncommon delayed reaction to injection.

Contraindications

PDRN injection is not suitable for all patients. Your practitioner must assess these factors before treatment.

Absolute Contraindications

  • ✕Fish or salmon allergy - PDRN is derived from salmon DNA
  • ✕Active skin infection in the treatment area
  • ✕Pregnancy
  • ✕Breastfeeding
  • ✕Known blood clotting disorder (e.g. haemophilia)
  • ✕Active autoimmune condition affecting the skin

Relative Contraindications

Discuss with your practitioner before treatment.

  • !Current anticoagulant or antiplatelet medication - increased bruising risk
  • !Active inflammatory skin conditions (e.g. active eczema flare, active psoriasis in treatment area)
  • !History of keloid scarring
  • !Recent laser or chemical peel in the treatment area - timing interval required
  • !Immunosuppressive therapy

Choosing a Qualified Practitioner

The most significant factor in treatment safety is practitioner training and technique. PDRN injections should be performed by doctors, nurses, or aesthetic clinicians with specific training in injectable treatments. Verify that your chosen clinic:

  1. 1Conducts a full medical consultation before treatment
  2. 2Uses sterile technique and single-use needles
  3. 3Can manage adverse events or refers to appropriate medical care
  4. 4Sources products from legitimate, traceable suppliers

Disclaimer: This information is educational. Your practitioner will conduct a full suitability assessment before treatment. Do not self-administer PDRN products.